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KMID : 0352819930090020039
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Kosin Medical Journal
1993 Volume.9 No. 2 p.39 ~ p.56
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Preliminary result of combined Hyperthermia(Cancermia GHT RF-8MHZ capacitive type) with Radiotherapy or chemotherapy in unresectable advanced malignant tumor -An analysis ofclinical response in 110 patients-
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Abstract
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110 patients with unresectable advanced malignant tumor treated with the combined hyperthermia and radiotherapy or chemotherapy at Kosin medical College and Medical center between April and December, 1992 were analyzed in short period of time
with
aspect to the local control rate, complication and fac0tors related with hyperthermia.
The anatomical sites treated with hypertheimia were head and neck(12 patients), chest(13 patients), abdomen(50 patients) and pelvis(35 patients). Among 73 patients received radiotherapy 62 patients(84.9%) were received hyperfractionated
radiotherapy(135cGy/Fr. 2 times/week) with 4-6MV Xray. among 39 patients received chemotherapy, 21 patients(53.8%) were injected 5-Fluorouracil with Interferon refimens and 18 patients (46.2%) with Adriamycin, Cisplatin and Etoposide regimens.
Hyperthermia started within 30minutes after radiltherapy, 2 times/week, 40-60 minutes withtotal 4-13 times(average : 8 times) in combined with radiotherapy, and 5-Fluorouracil (5-Fluorouracil with Interferon regimens) was injected simultaneously
at
day
1, 6, and day 1, 8 with Adriamycin (Adriamycin, cisplatin with Etoposide regimens) in combined withchemotherapy.
The overall localcontrol rate (CR+PR0 was obtained at 6 months after treatment was 63%(CR 17%/PR47%). Local control rate by combined hyperthermia with radiotherapy was 76%(CR 24%/PR52%) and 41% by combined with chemotherapy (CR 3%/PR 38%)
Hyperthermia combined with radiotherapy had showed superior results than combined withchemotherapy and the intratumoral temperature more than 40.1。C and /or hyperthermia number(time) more than 8 times had high local control rates. The most
common
complications by hyperthermia were mild or moderate skin burns with pain and most serious complication was subcutaneous fat necrosis. The factors influenced to result of hyperthermia were intratumoral temperature, number(time) ofhyperthermia and
treatment modality.From above study we concluded that hyperthermia cobined withradiotherapy or chemotherapy might be better treatment modality for increased local control and palliative effect in unresectable advanced malignant tumor with/without
intractable pain.
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KEYWORD
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